Endocrine Abstracts

Vesicular thyroid tumours evolve from benign to malignant states, respectively called adenomas and carcinomas by respect to the World Health Organisation classification. Borderline cases, atypical adenomas, cannot be clearly classified. When an abnormal cytoplasmic mitochondrial proliferation occurs into the tumour cells, these tumours called oncocytomas, are more aggressive. Oncogenic mechanisms and signal pathways of these tumours are not well known and the origin of the onc...

Resistance to thyroid hormones (RTH), is with the exceptions caused by mutations in the gene coding β1-subunit of the thyroid receptor (TRβ1) located on chromosome 3. More than 700 individuals with RTH belonging to about 250 families have been identified up to date. The presence of goiter, tachycardia and hyperactivity together with abnormal findings on routine thyroid testing usually lead to further investigation and, ultimately, the diagnosis ...